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European Heart Journal 1994 15(10):1396-1402;
Copyright © 1994 by the European Society of Cardiology.
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© 1994 The European Society of Cardiology

A clinical study of amiodarone as a single oral dose in patients with recent-onset atrial tachyarrhythmia

P. ANDRIVET, E. BOUBAKRI, P. J. DOVE, V. MACH and C. VU NGOC

Cardiology-Pneumology Intensive Care Unit, and the Cardiology Department, Centre Médico-Chirurgical de Bligny, Briis-sous-Forges France

Received 20 January 1994; revised 22 March 1994; .

Correspondence. Dr P Andrivet, CMC Bligny, 91640 Briis/Forges, France.

Abstract

Forty-five patients with recent-onset sustained atrial tachyarrhythmia (mean heart rate at entry; 140.0± 3.5 beats. min–1) associated with various cardiovascular diseases were treated by oral amiodarone, given as a single loading dose of 25.7± 0.9 mg. kg–1 body weight. Conversion to sinus rhythm was observed in 29 patients during the first 24 h of treatment, leading to a success rate of 64.4%. Five additional patients converted to sinus rhythm with continuation of oral amiodarone, (10–15 mg. kg–1 by day) with a mean delay of 4.2 days. A similar population of 27 patients (mean heart rate at entry; 140 ± 3 beats. min–1) was treated by intravenous amiodarone, given as a bolus infusion of 3–5mg. kg–1 over 30min (mean; 41±02 mg. kg–1), followed by a continuous infusion of 10–15mg. kg–1 for 24 h (mean; 11.1±0.7 mg. kg–1). Eighteen patients converted to sinus rhythm during the first 24 h of therapy, leading to a success rate of 66.7%. Minor adverse effects of therapy were observed in two patients given oral amiodarone, and in seven given intravenous amiodarone. No major effect was observed. We suggest that amiodarone given as a single oral loading dose of 25–30mg. kg–1 body weight is an effective, simple and well-tolerated therapy, suitable for most patients with recent-onset ATA.

Key Words: Atrial tachyarrhythmia • amiodarone • oral


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