Skip Navigation

European Heart Journal 1994 15(12):1666-1672;
Copyright © 1994 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by CUCCHINI, F.
Right arrow Articles by VlSIOLI, O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by CUCCHINI, F.
Right arrow Articles by VlSIOLI, O.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1994 The European Society of Cardiology

Do inotropic drugs always induce a positive lusitropic effect? A comparison between k-strophanthidin and dobutamine in patients with coronary artery disease

F. CUCCHINI, R. BOLOGNESI*, A. JAVERNARO, R. ZEPPELLINI, R. DE DOMENICO and O. VlSIOLI*

Division of Cardiology, Bassano del Grappa (VI) Italy
*Chair of Cardiology, University Parma and Brescia Italy

Received 15 February 1994; revised 21 June 1994; .

Correspondence: Prof. Francesco Cucchini, Divisine di Cardiologia, Via delle Fosse 43, 36061 Bassano del Grappa, Vicenza, Italy.

Abstract

The interaction between systolic and diastolic effects of inotropic drugs is an important subject which has not yet been fully clarified in the cardiological literature.

The effects of the inotropic drugs k-strophanthidin and dobutamine on left ventricular (LV) relaxation and early filling phase were compared in patients with coronary artery disease (CAD) and preserved systolic function.

Twenty-two patients were randomly divided into two groups; group I was infused with 0.0035mg. kg–1 of k-strophanthidin for 10 min and group II with dobutamine at a rate of 10 fig. kg–1. min–1 for 10 min. Both groups underwent simultaneous haemodynamic and echo 2D-Doppler evaluations at controlled heart rate.

K-strophanthidin improved contractility indexes (peak of LV systolic pressure P<0.001, max dPldt+ P<0.05 and dPIdt P<0.01) and worsened T constant and LV lowest diastolic pressure, (LVLDP) (P<0.001 and P<0.05 respectively) without changing early transmitral filling parameters. Dobutamine induced a significant increase in contractility in group II but at the same time significantly improved LV relaxation variables (max dPIdt– P<0.01 and T constant P<0.001). In addition, dobutamine reduced LVLDP (P<0.05) and significantly increased LV early filling parameters.

These results show that an acute administration of either k-strophanthidin or dobutamine enhances contractility, whereas these drugs have the opposite effect on the early diastolic phase.

Key Words: k-strophanthidin • dobutamine • CAD patients • systolic-diastolic interaction


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.