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European Heart Journal 1994 15(2):179-183;
Copyright © 1994 by the European Society of Cardiology.
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© 1994 The European Society of Cardiology

Oxidative stress in patients with unstable angina

J. L. DUBOIS-RANDÉ*,, J. Y. ARTIGOU{dagger}, J. Y. DARMON{ddagger}, R. HABBAL*, C. MANUEL{ddagger}, I. TAYARANI{ddagger}, A. CASTIGNE* and Y. GROSGOGEAT{dagger}

*Services de Cardiologie, Centre Hospitalo– Universitaire Henri Mondor
{dagger}Services de Cardiologie, et Pitié Salpetrièret
{ddagger}Services de Bioxytech

Received 20 May 1993; revised 29 September 1993; .

Coresspondence: Jean Luc Dubois-Randé, MD, Service de Cardiologie, Hopital Henri Mondor, 51 avenue du maréchal De Lattre de Tassigny, Creteil 94010, France

Abstract

The aim of this study was to determine whether oxidative stress occurs in unstable angina. Thirty patients with unstable angina class B (Braunwald classification) were prospectively studied Control groups consisted of 23 patients presenting with stable angina and of 2l age-matched healthy volunteers. Upon admission and every 8 h for 24 h, blood samples were drawn for the determination of plasma malondialdehyde (MDA) levels, Se-glutathione peroxidase (GPX) activity, erythrocyte reduced glutathione (GSH) concentrations, erythrocyte GPX and superoxide dismutase (SOD) activities. Coronary angiograms were performed within 4 days of admission in 26 out of the 30 patients included in the study. Nine of these 30 patients were subsequently ident as presenting a non-Q wave myocardial infarction and were separately examined. On admission, only plasma MDA levels and erythrocyte GSH concentrations differed among groups. Plasma MDA levels of patients presenting with unstable angina (P<0·01) and acute myocardial infarction (P<0·05) were higher than those of patients with stable angina and of normal volunteers, whereas there was no difference in these parameters between unstable angina and non-Q wave myocardial infarction groups. Erythrocyte GSH concentration was lower in all patient groups as compared to normal subjects. ANOVA for repeated measures showed no d between admission and subsequent levels for all parameters. Finally, no difference was observed for any of the parameters when anti-ischaemic or anti-aggregant treatment before admission, or the number of affected vessels on coronary angiograms, were considered. We conclude that an oxidative stress can be evidenced in patients with unstable angina or acute myocardial infarction.

Key Words: Unstable angina • oxidative stress • free radicals


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