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European Heart Journal 1994 15(2):247-254;
Copyright © 1994 by the European Society of Cardiology.
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© 1994 The European Society of Cardiology

Effects of ramipril on the neurohormonal response to exercise in patients with mild or moderate congestive heart failure

A. SIGURDSSON, K. SWEDBERG and B. ULLMAN*

From the Division of Cardiology, Department of Medicine, Östra Hospital Göteborg Söder Hospital, Stockholm, Sweden
*From the Division of Cardiology, Department of cardiology Söder Hospital, Stockholm, Sweden

Received 17 May 1993; revised 23 August 1993; .

Coresspondence: Axel Sigurdsson, MD, Division of Cardiology, Department of Medicine, Östra Hospital, 416 85 Göteborg, Sweden

Abstract

Static measurements of plasma neurohormones at rest may not be adequate to detect alterations in cardiovascular control mechanisms in congestive heart failure (CHF). Therefore, it is of interest to study neurohormonal activation during different physiological conditions. Plasnw neurohormones were measured in 54 patients on diuretic therapy for mild or moderate CHF. Samples were taken at rest and immediately after maximal bicycle exercise, before and after 12 weeks of treatment with ramipril or placebo. There was a strong correlation between the plasma levels of each hormone before and after exercise. An inverse correlation existed at baseline between exercise duration and angiotensin II levels after maximal exercise (r= – 0·30, P=0·03), but not at rest. Plasma levels of angiotensin II, aldosterone, atrial natriuretic peptide (ANP) and noradrenaline were increased after maximal exercise compared to rest. Plasma angiotensin converting enzyme activity and ANP were reduced by ramipril compared to placebo, both at rest and after exercise, but levels of angiotensin II, aldosterone and nordrenaline were not significantly affected Thus, exercise consistently activates neurohormonal systems in patients with CHF. Patients with the lowest exercise duration had the highest angiotensin II levels after exercise. Measurements of plasma neurohormones after maximal exercise provide limited additional value to measurements at rest.

Key Words: Neurohormonal activation • heart failure • exercise • ramipril • angiotensin converting enzyme inhibitors


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