Copyright © 1994 by the European Society of Cardiology.
© 1994 The European Society of Cardiology
The role of elastic recoil after balloon angioplasty of rabbit arteries and its prevention by stent implantation
BLER
Department of Cardiology and Anatomy Germany
*Department of Cardiology and Anatomy University of Heidelberg Germany
Received 10 May 1993; revised 23 August 1993; .
Coresspondence: Christoph Hehrlein, MD, Department of Cardiology, University of Heidelberg, Bergheimerstr. 58, 69115 Heidelberg, Germany
Abstract
Elastic recoil, neointima formation and vessel narrowing after balloon angioplasty or stent implantation were compared in 17 non-atherosclerotic New Zealand White rabbits. The implantation of a balloon-expandable Palmaz-Schatz stent was performed in one iliac artery and a balloon angioplasty alone was performed in the contralateral artery (n=34 arteries). Quantitative histomorphometry was performed by a computer-assisted analysis 1 h and 4, 10 and 24 weeks after the initial procedure. The histological appearance of the neointima was similar to that of human restenosis. The amount of the neointima was increased within sten ted vessels as compared to balloon angioplasty alone (1·0±0·1 vs 0·4±0·1 mm2 at 4 weeks, P<0·001). However, the neointimal lumen narrowing was smaller in the stented vessels due to persistent increase in vessel perimeter as compared to balloon angio plasty alone (16·5±0·9 vs 34·7±16·5% lumen narrowing at 4 weeks, P<0·05). In conclusion, stent implantation enhances neointima formation as compared to angioplasty in non-atherosclerotic rabbits. The prevention of elastic recoil after stent implantation, however, reduces the neointimal lumen narrowing. This study supports clinical observations demonstrating lower restenosis rates after stent implantation compared to standard balloon angioplasty.
Key Words: Angioplasty • elastic recoil • intimal hyperplasia • restenosis • stent implantation
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