Skip Navigation

European Heart Journal 1994 15(3):335-338;
Copyright © 1994 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by KUNISHIMA, S.
Right arrow Articles by OHNO, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by KUNISHIMA, S.
Right arrow Articles by OHNO, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1994 The European Society of Cardiology

Chrome congestive heart failure

Activation and destruction of platelets in patients with rheumatic heart disease

S. KUNISHIMA*,, M. HATTORI{dagger}, S. KOBAYASHI*, H. HATTORI{dagger}, Y. IWAMA{dagger}, Y. IMAI{dagger}, K. OGAWA{dagger}, T. NAOE{ddagger} and R. OHNO{ddagger}

*Departments of Central Clinical Laboratory 1–3–1 Sannomaru, Naka-ku, Nagoya 460
{dagger}Cardiology, Meijo Hospital 1–3–1 Sannomaru, Naka-ku, Nagoya 460
{ddagger}Department of Internal Medicine, Branch Hospital, Nagoya University School of Medicine 1–1–20 Daiko-Minami, Higashi-ku, Nagoya 461, Japan

Received 10 November 1992; revised 25 October 1993; .

Correspondence: Shinji Kunishisna, Department of Central Clinical Laboratory, Meijo Hospital, 1-3-1 Sannomaru, Naka-ku, Nagoya 460, Japan

Abstract

We evaluated the activation and destruction of platelets in 24 patients with rheumatic heart disease (RHD) involving the mitral valve. Ex vivo platelet aggregation induced by adenosine diphosphate (ADP) and collagen was significantly increased in RHD patients as compared with normal controls. Plasma levels of ß-thromboglobulin (ß-TG) and platelet factor 4 were also elevated Plasma concentrations of glycocalicin, a proteolytic fragment of platelet membrane glycoprotein Ib. were increased, while platelet counts were decreased in RHD patients as compared with normal controls. RHD patients with, versus those without, atrial fibrillation demonstrated significant differences in ß-TG levels and platelet counts. However, we observed no difference in glycocalicin levels between the two groups. The present study demonstrated that increased platelet activation, as well as platelet destruction, occur in patients with RHD.

Key Words: Atrial fibrillation • glycocalicin • glycoprotein Ib • platelet aggregation • platelet factor 4 • ß-thromboglobulin


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 ANGIOLOGYHome page
S. Topaloglu, A. Boyaci, S. Ayaz, S. Yilmaz, O. Yanik, O. Ozdemir, M. Soylu, A. D. Demir, D. Aras, H. L. Kisacik, et al.
Coagulation, Fibrinolytic System Activation and Endothelial Dysfunction in Patients With Mitral Stenosis and Sinus Rhythm
Angiology, February 1, 2007; 58(1): 85 - 91.
[Abstract] [PDF]

Home page
 ChestHome page
M.-C. Chen, H.-W. Chang, C.-J. Wu, C.-H. Yang, W. C. Hung, K.-H. Yeh, and M. Fu
Percutaneous Transluminal Mitral Valvuloplasty Reduces Circulating Soluble CD40 Ligand in Rheumatic Mitral Stenosis
Chest, July 1, 2005; 128(1): 36 - 41.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M.-C. Chen, H.-W. Chang, S.-S. Juang, H.-K. Yip, and C.-J. Wu
Increased Plasma Levels of Soluble P-Selectin in Rheumatic Mitral Stenosis
Chest, July 1, 2004; 126(1): 54 - 58.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M.-C. Chen, C.-J. Wu, H.-W. Chang, H.-K. Yip, Y.-H. Chen, C.-I Cheng, and H.-T. Chai
Mechanism of Reducing Platelet Activity by Percutaneous Transluminal Mitral Valvuloplasty in Patients With Rheumatic Mitral Stenosis
Chest, May 1, 2004; 125(5): 1629 - 1634.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M.-C. Chen, C.-J. Wu, H.-K. Yip, H.-W. Chang, C.-Y. Fang, T.-H. Yu, and M. Fu
Left Atrial Platelet Activity With Rheumatic Mitral Stenosis: Correlation Study of Severity and Platelet P-Selectin Expression by Flow Cytometry
Chest, November 1, 2003; 124(5): 1663 - 1669.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
S. Kamath, A. D. Blann, B. S. P. Chin, F. Lanza, B. Aleil, J. P. Cazenave, and G. Y. H. Lip
A study of platelet activation in atrial fibrillation and the effects of antithrombotic therapy
Eur. Heart J., November 2, 2002; 23(22): 1788 - 1795.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
S. Kamath, A.D. Blann, and G.Y.H. Lip
Platelets and atrial fibrillation
Eur. Heart J., December 2, 2001; 22(24): 2233 - 2242.
[PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.