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European Heart Journal 1994 15(3):377-381;
Copyright © 1994 by the European Society of Cardiology.
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© 1994 The European Society of Cardiology

Chrome congestive heart failure

Study of low dosage prostaglandin—usages and complications

G. K. SINGH*,, L. V. FONG{dagger}, A. P. SALMON{ddagger} and B. R. KEETON{ddagger}

*St Christopher's Hospital for Children Philadelphia, U.S.A.
{dagger}Royal Children's Hospital Melbourne, Australia
{ddagger}Wessex Regional Cardiothoracic Centre, Southampton General Hospital Southampton, U.K.

Received 19 August 1993; .

Correspondence: Robert J. Siegel, MD, FACC, Division of Cardiology Rm 5314, 8700 Beverly Boulevard, Los Angeles, CA. 90048, U.S.A.

Abstract

Low dosage intravenous (<0·01 µg. kg–1. min–1) and oral prostaglandin E have been reported to produce fewer complications than higher intravenous doses in the ductal manipulation of congenital heart disease. Over a 3-year period 34 patients were treated with low dosage intravenous or oral prosraglandin. Eighteen (53%) had complications associated with this treatment with 14 having more than one complication. Major complications occurred in nine neonates: necrotising enterocolitis (7), apnoealbradycardia (5), convulsions (1), haemorrhage (1), and resulted in a change of management. This study therefore concludes that the high incidence of complications is similar with both low and high dosages of intravenous and oral prostaglandmn. The use of prostaglandin in any form deserves caution.

Key Words: Low dosage prostaglandin E • complication • congenital heart disease


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