Copyright © 1994 by the European Society of Cardiology.
© 1994 The European Society of Cardiology
Early accumulation of the terminal complement-complex in the ischaemic myocardium after reperfusion
*Department of Cardiology, University Hospital Eppendorf Hamburg, Germany
Department of Pathology, University Hospital Eppendorf Hamburg, Germany
Institutes of Medical Microbiology, Universities of Gießen Germany
Institutes of Medical Microbiology, Universities of Mainz Germany
Received 16 December 1992; revised 19 October 1993; .
Correspondence Prof Dr D. Mathey/Prof. Dr J. Schofer und Partner, Innere Medizin-Kardiologie, Othmarscher Kirchenweg 168, 22763 Hamburg, Germany
Abstract
The terminal, membrane-damaging complement complex C5b-9 accumulates in the infarcted myocardium. In experimental myocardial infarction, we investigated the time course of C5b-9 deposition and the influence of reperfusion. In a group of 17 rabbits (group 1), the circumflex coronary artery was occluded for different time periods ranging from 0•5 to 29 h without subsequent reperfusion. A second group of 23 rabbits (group 2) underwent coronary artery occlusion for periods ranging from 0•5 to 6 h followed by reperfusion. C5b-9 was determined in transmural myocardial biopsies by immunohistochemistry and by ELISA. In group 1, C5b-9 accumulation in the ischaemic myocardium was found only after 5 to 6 h of coronary artery occlusion. In group 2 (ischaemia and reperfusion), significant C5b-9 deposition was already observed after 30 min of myocardial ischaemia.
We conclude that in the absence of reperfusion C5b-9 accumulation occurs as a late event when most of the jeopardized myocardium has probably already become necrotic. In the presence of reperfusion, however, the complement system is activated rapidly and this could play a role in the pathogenesis of reperfusion injury.
Key Words: Complement system • myocardial infarction • reperfusion injury
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  Y. Banz, O. M. Hess, S. C. Robson, D. Mettler, P. Meier, A. Haeberli, E. Csizmadia, E. Y. Korchagina, N. V. Bovin, and R. Rieben Locally targeted cytoprotection with dextran sulfate attenuates experimental porcine myocardial ischaemia/reperfusion injury Eur. Heart J., November 1, 2005; 26(21): 2334 - 2343. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. B. Granger, K. W. Mahaffey, W. D. Weaver, P. Theroux, J. S. Hochman, T. G. Filloon, S. Rollins, T. G. Todaro, J. C. Nicolau, W. Ruzyllo, et al. Pexelizumab, an Anti-C5 Complement Antibody, as Adjunctive Therapy to Primary Percutaneous Coronary Intervention in Acute Myocardial Infarction: The COMplement inhibition in Myocardial infarction treated with Angioplasty (COMMA) Trial Circulation, September 9, 2003; 108(10): 1184 - 1190. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. D. Barrett, J. K. Hennan, R. M. Marks, and B. R. Lucchesi C-Reactive-Protein-Associated Increase in Myocardial Infarct Size After Ischemia/Reperfusion J. Pharmacol. Exp. Ther., December 1, 2002; 303(3): 1007 - 1013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. de Zwaan, A.H. Kleine, J.H.C. Diris, J.F.C. Glatz, H.J.J. Wellens, P.F.W. Strengers, M. Tissing, C.E. Hack, M.P. van Dieijen-Visser, and W.T. Hermens Continuous 48-h C1-inhibitor treatment, following reperfusion therapy, in patients with acute myocardial infarction Eur. Heart J., November 1, 2002; 23(21): 1670 - 1677. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Buerke, H. Schwertz, W. Seitz, J. Meyer, and H. Darius Novel Small Molecule Inhibitor of C1s Exerts Cardioprotective Effects in Ischemia-Reperfusion Injury in Rabbits J. Immunol., November 1, 2001; 167(9): 5375 - 5380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. R. Lucchesi Looking Toward the Future, Using Lessons from the Past J. Pharmacol. Exp. Ther., June 1, 2001; 297(3): 829 - 836. [Abstract] [Full Text]
|
|
|
|
 |
|
 U. Klima, I. Kutschka, G. Warnecke, P. Kim, M. Struber, M. Kirschfink, and A. Haverich Improved right ventricular function after intracoronary administration of a C1 esterase inhibitor in a right heart transplantation model Eur. J. Cardiothorac. Surg., September 1, 2000; 18(3): 321 - 327. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Park and B. R. Lucchesi Mechanisms of myocardial reperfusion injury Ann. Thorac. Surg., November 1, 1999; 68(5): 1905 - 1912. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. D. Collard, A. Agah, W. Reenstra, J. Buras, and G. L. Stahl Endothelial Nuclear Factor-{kappa}B Translocation and Vascular Cell Adhesion Molecule-1 Induction by Complement : Inhibition With Anti-Human C5 Therapy or cGMP Analogues Arterioscler. Thromb. Vasc. Biol., November 1, 1999; 19(11): 2623 - 2629. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Jordan, Z.-Q. Zhao, and J. Vinten-Johansen The role of neutrophils in myocardial ischemia-reperfusion injury Cardiovasc Res, September 1, 1999; 43(4): 860 - 878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. K. Lagrand, C. A. Visser, W. T. Hermens, H. W. M. Niessen, F. W. A. Verheugt, G.-J. Wolbink, and C. E. Hack C-Reactive Protein as a Cardiovascular Risk Factor : More Than an Epiphenomenon? Circulation, July 6, 1999; 100(1): 96 - 102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.W.M. Niessen, W.K. Lagrand, C.A. Visser, C.J.L.M. Meijer, and C.E. Hack Upregulation of ICAM-1 on cardiomyocytes in jeopardized human myocardium during infarction Cardiovasc Res, March 1, 1999; 41(3): 603 - 610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Schmiedt, R. Kinscherf, H.-P. Deigner, H. Kamencic, O. Nauen, J. Kilo, H. Oelert, J. Metz, and S. Bhakdi Complement C6 Deficiency Protects Against Diet-Induced Atherosclerosis in Rabbits Arterioscler. Thromb. Vasc. Biol., November 1, 1998; 18(11): 1790 - 1795. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Yasojima, C. Schwab, E. G. McGeer, and P. L. McGeer Human Heart Generates Complement Proteins That Are Upregulated and Activated After Myocardial Infarction Circ. Res., October 19, 1998; 83(8): 860 - 869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Buerke, D. Prüfer, M. Dahm, H. Oelert, J. Meyer, and H. Darius Blocking of Classical Complement Pathway Inhibits Endothelial Adhesion Molecule Expression and Preserves Ischemic Myocardium from Reperfusion Injury J. Pharmacol. Exp. Ther., July 1, 1998; 286(1): 429 - 438. [Abstract] [Full Text]
|
|
|
|
|
|
K. Yasojima, K. S. Kilgore, R. A. Washington, B. R. Lucchesi, and P. L. McGeer Complement Gene Expression by Rabbit Heart : Upregulation by Ischemia and Reperfusion Circ. Res., June 15, 1998; 82(11): 1224 - 1230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. S. Kilgore, K. B. Naylor, E. J. Tanhehco, J. L. Park, E. A. Booth, R. A. Washington, and B. R. Lucchesi The Semisynthetic Polysaccharide Pentosan Polysulfate Prevents Complement-Mediated Myocardial Injury in the Rabbit Perfused Heart J. Pharmacol. Exp. Ther., June 1, 1998; 285(3): 987 - 994. [Abstract] [Full Text]
|
|
|
|
|
|
C. D. Collard, A. Vakeva, C. Bukusoglu, G. Zund, C. J. Sperati, S. P. Colgan, and G. L. Stahl Reoxygenation of Hypoxic Human Umbilical Vein Endothelial Cells Activates the Classic Complement Pathway Circulation, July 1, 1997; 96(1): 326 - 333. [Abstract] [Full Text]
|
|
|
|
|
|
G. Horstick, A. Heimann, O. Gotze, G. Hafner, O. Berg, P. Boehmer, P. Becker, H. Darius, H.-J. Rupprecht, M. Loos, et al. Intracoronary Application of C1 Esterase Inhibitor Improves Cardiac Function and Reduces Myocardial Necrosis in an Experimental Model of Ischemia and Reperfusion Circulation, February 4, 1997; 95(3): 701 - 708. [Abstract] [Full Text]
|
|