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European Heart Journal 1994 15(4):468-471;
Copyright © 1994 by the European Society of Cardiology.
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© 1994 The European Society of Cardiology

Serum lipids and thyrotropin in women with coronary artery disease

P. J. STUBBS{dagger},, B. D. MULROONEY*, P. O. COLLLNSON**, P. B. S. FOWLER{ddagger} and M. I. M. NOBLE{dagger}

{dagger}Academic Unit of Cardiovascular Medicine, Charing Cross and Westminster Medical School West Middlesex University Hospital U.K.
*Department of Cardiology, West Middlesex University Hospital U.K.
**Department of Chemical Pathology, Mayday University Hospital U.K.
{ddagger}Department of Medicine Charing Cross Hospital U.K.

Received 23 July 1993; revised 26 October 1993; .

Correspondence Dr Peter John Stubbs, Academic Unit of Cardiovascular Medicine, 4th Floor, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, U.K.

Abstract

Abnormalities of thyroid function are associated with changes in lipid concentrations and in the incidence of ischaemic heart disease. Whether lipid concentration and thyroid function are related when thyroid function is normal in ischaemic heart disease is uncertain. This study was undertaken to investigate the relationship between thyroid function, serum lipids and ischaemic heart disease in euthyroid women.

Forty-six euthyroid patients were studied. Patients with diseases known to affect lipid levels or receiving drugs known to alter lipid or thyroid metabolism were excluded Twenty-three had ischaemic heart disease (IHD) and were matched with 23 controls. Correlations were found between thyrotropin (TSH) and cholesterol (P=0·05) low density lipoprotein (LDL) (P=0·09) and triglyceride (P=0·009 in the IHD group but not between any serum lipids and TSH in the control group. Analysis of covariance showed a statistically significant difference between groups of the association between cholesterol and TSH (P<0·05 (slope) P<0·001 (means)), LDL and TSH (P<0·005 (means)) and between triglyceride and TSH (P<0·05 (means)). This study suggests that TSH within the normal range is having a statistically significant effect on lipid levels in women with ischaemic heart disease.

Key Words: Thyrotropin • coronary artery disease • female • lipids


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