Skip Navigation

European Heart Journal 1994 15(4):541-546;
Copyright © 1994 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by KORNOWSKI, R.
Right arrow Articles by BATTLER, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by KORNOWSKI, R.
Right arrow Articles by BATTLER, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1994 The European Society of Cardiology

Low molecular weight heparin (Fragmin®) prevents early reocclusion following femoral artery thrombolysis with rt-PA in rabbits

R. KORNOWSKI, M. GLIKSON, D. HASDAI, A. CHERNINE, D. OHAD and A. BATTLER

The Neufeld Cardiac Research Institute, Sackler Faculty of Medicine, Tel Aviv University Tel Aviv, Israel

Received 6 July 1993; revised 21 October 1993; .

Correspondence: Ram Kornowski, MD, The Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Haahomer 52621, Israel

Abstract

The purpose of this study was to evaluate the effect of low molecular weight heparin Fragmin on thrombolysis with tissue-type plasminogen activator (rt-PA) and to compare its effect to that of standard heparin. A rabbit thrombosis model was used, consisting of a blood clot produced in an isolated femoral artery segment with superimposed endothelial damage and distal stenosis. Thirty rabbits were randomized to three treatment groups with rt-PA (30 µ.g. kg–1. min–1 for 60 min and no additional therapy), rt-PA with Lv. standard heparin (200 IV. Kg–1 bolus and then 70 IU. Kg–1 hourly) and rt-PA with s.c. Fragmin (a single dose of 500 IU. Kg–1) prior to rt-PA administration. In six of 10 rabbits given rt-PA only, recanalization was observed, which was persistent in three. In eight of 10 rabbits given rt-PA with intravenous heparin, reflow was achieved, which was persistent in three. Fragmin resulted in recanalization in eight of 10 rabbits, with persistent patency in each recanalized rabbit. Reflow time was not shortened with either standard heparin or Fragmin compared with rt-PA alone (64±41, 56 ± 18, 50 ±23 min respectively), (P=0·7). Persistent reocclusion after reflow was not observed with Fragmin (0/8) but was present with both standard heparin (518, P=0·03 vs Fragmin) and rt-PA alone (316, P=0·05 vs Fragmin).

Thus, in the femoral artery of the rabbit, Fragmin, unlike standard heparin, was found to prevent reocclusion following rt-PA thrombolysis.

Key Words: Thrombosis • thrombolysis • heparin • heparinoid • rabbits


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.