Copyright © 1994 by the European Society of Cardiology.
© 1994 The European Society of Cardiology
Serum triglycerides and HDL cholesterol — major predictors of long-term survival after coronary surgery
The Wallenberg Laboratory for Cardiovascular Research, Division of Cardiology, Sahlgren's Hospital,University of Göteborg Göteborg, Sweden
Received 30 April 1993; revised 25 November 1993; .
Correspondence: Tomas Lindén MD PhD, Wallenberg Laboratory, Sahlgren's Hospital S-413 45 Gothenburg, Sweden.
Abstract
The influence of pre-operative serum lipid levels on late clinical outcome after coronary artery bypass surgery was analysed in 83 patients undergoing coronary bypass surgery for stable angina pectoris. The mean follow-up period for surviving patients was 105±33 months (range 65–133). Twenty-two patients (27%) had died during follow-upt of whom 14 had sustained a fatal myocardial infarction and four had succumbed to other cardiovascular causes. Thirty-one patients sustained 35 cardiac events, defined as either fatal or non-fatal myocardial infarction, or reoperation, or PTCA during the follow-up period. With univariate analysis, pre-operative serum levels of total cholesterol and triglycerides were significantly related to cardiac events, P<0.05 and P<0.05, respectively. In a Cox proportional analysis, cardiac mortality and total mortality were related to serum triglycerides and HDL cholesterol (P<0.05 and P<0.01 respectively). Eighty-five percent of the patients with triglycerides <2.0 mm. l–1 survived for 10 years, while only 48% of patients with triglycerides >2.0 mM. 1–1 remained alive for that period. Figures were similar for subjects with HDL cholesterol >1.0mM. I–1 or HDL cholesterol <1.0 mM. I–1, at 89 and 38%, respectively.
Only 28% of the patients with the combination triglycerides >2.0 mM. I–1 and HDL cholesterol <1.0 mM. I–1 were alive 10 years after surgery. These data suggest that dyslipidaemia, especially the combination of high serum triglycerides and low HDL cholesterol, is an important factor influencing long-term clinical outcome after coronary bypass surgery.
Key Words: Coronary bypass surgery • serum lipoproteins • apolipoproteins AI and B • HDL cholesterol • serum triglycerides • cardiovascular events • long-term survival
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  P N Durrington, D Bhatnagar, M I Mackness, J Morgan, K Julier, M A Khan, and M France An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia Heart, May 1, 2001; 85(5): 544 - 548. [Abstract] [Full Text]
|
|
|
|
|
|
J S Skinner, M Farrer, C J Albers, H A W Neil, and P C Adams High apolipoprotein AI concentrations are associated with lower mortality and myocardial infarction five years after coronary artery bypass graft surgery Heart, May 1, 1999; 81(5): 488 - 494. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. G. Motwani and E. J. Topol Aortocoronary Saphenous Vein Graft Disease : Pathogenesis, Predisposition, and Prevention Circulation, March 10, 1998; 97(9): 916 - 931. [Abstract] [Full Text] [PDF]
|
|