Skip Navigation

European Heart Journal 1994 15(6):753-760;
Copyright © 1994 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by FlGUERAS, J.
Right arrow Articles by LIDÓN, R. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by FlGUERAS, J.
Right arrow Articles by LIDÓN, R. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1994 The European Society of Cardiology

Circadian rhythm of angina in patients with unstable angina: relationship with extent of coronary disease, coronary reserve and ECG changes during pain

J. FlGUERAS and R. M. LIDÓN

Unitat Coronaria, Servei de Cardiologia, Hospital General Vall d'Hebrón Barcelona, Spain

Received 2 September 1993; revised 20 December 1993; .

Correspondence: Jaime Figueras, MD, Unitat Coronaria, Servei de Cardio-logia, Hospital General Vall d'Hebrón, Passeig Vall d'Hebrón s/n, 08035 Barcelona, Spain.

Abstract

A circadian distribution of ischaemic events has been identified in ambulatory patients with stable angina. However, whether a similar distribution occurs in patients with unstable angina who remain at bed rest is still uncertain. Therefore, we analysed the possible circadian presentation of episodes of angina at rest (n=1222) in 193 patients hospitalized consecutively. The influence of extent of coronary disease (number of vessels with >70% stenosis, 0, 1 and 2–3), type of ECG changes during pain on a 12-lead ECG, and coronary reserve, as assessed by ischaemic threshold (atrial pacing), were also evaluated. There were two peaks of highest incidence: at 0700–1000h and at 1900–2200h (P<0.0001) which were unrelated to the extent of coronary disease, coronary reserve or type of ECG change. Patients with 1 or 2-3 vessel disease with a reduced ischaemic threshold (=<150 beats. min –1), however, had a higher incidence of midnight angina (2300–0200h) than those with a normal threshold or with no vessel disease (P<0001).

It is concluded that, in spite of being at bed rest, patients with unstable angina present a definite circadian distribution of angina, with peaks in the early morning and late evening. Patients with a low coronary reserve seem to have a higher incidence of midnight angina than others.

Key Words: Unstable angina • angina at rest • circadian rhythm • atrial pacing


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 CirculationHome page
D. J. Patel, C. J. Knight, D. R. Holdright, D. Mulcahy, D. Clarke, C. Wright, H. Purcell, and K. M. Fox
Pathophysiology of Transient Myocardial Ischemia in Acute Coronary Syndromes: Characterization by Continuous ST-Segment Monitoring
Circulation, March 4, 1997; 95(5): 1185 - 1192.
[Abstract] [Full Text]

Home page
 CirculationHome page
J. Figueras and R. M. Lidon
Early Morning Reduction in Ischemic Threshold in Patients With Unstable Angina and Significant Coronary Disease
Circulation, October 1, 1995; 92(7): 1737 - 1742.
[Abstract] [Full Text]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.