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European Heart Journal 1994 15(6):769-780;
Copyright © 1994 by the European Society of Cardiology.
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© 1994 The European Society of Cardiology

Predictors of left ventricular mass in old age: an echocardiographic, clinical and biochemical investigation of a random population sample

M. LINDROOS, M. KUPARI, J. HEIKKILÁ and R. TILVIS*

Division of Cardiology, First Department of Medicine and the Geriatric Unit, Helsinki University Central Hospital Helsinki, Finland
*Second Department of Medicine, Helsinki University Central Hospital Helsinki, Finland

Received 3 September 1993; revised 1 February 1994; .

Correspondence: Magnus Lindroos, MD, Central Hospital of Vaasa, 65130 Vaasa, Finland.

Abstract

The potential predictors of left ventricular mass in old age were studied in a random sample of people born in 1904, 1909, 1914 (n=501; and 1920-35 (n=76). Data on the left ventricle with mass calculation, quantitative data on value disorders and biochemical data were collected. Left ventricular mass (corrected for height) was positively related to male gender, age, body mass index and systolic blood pressure. It was also significantly higher in the presence of aortic valve calcification, a low velocity ratio (indicating aortic value obstruction), and aortic or mitral re gurgitation. In men, left ventricular mass was higher in the presence of coronary artery disease and inversely related to serum high density lipoprotein cholesterol. In multivariate analysis, independent predictors of left ventricular mass without sex interaction were age (standardized coefficient ß=0.23, P=0.000). male gender (ß=0.38, P=0.000), body mass index (ß=0.22, P=0.000), systolic blood pressure (ß=0.21, P=0.000), velocity ratio (ß=-0.11, P=0.010), detectable aortic regurgitation (ß=0.11, P=0.014) and moderate-to-severe mitral regurgitation (ß=0.21, P=0.014) and moderate-to-severe mitral regurgitation (ß=0.21, P=0.000). Thus, the increase in left ventricular mass with age can largely be related to discrete predictors. The impact of valve disorders is substantial.

Key Words: Left ventricular mass • old age • echocardiography • hypertension • aetiology


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