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European Heart Journal 1994 15(6):832-841;
Copyright © 1994 by the European Society of Cardiology.
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© 1994 The European Society of Cardiology

Determination of left ventricular mass with electron beam computed tomography in deformed, hypertrophic human hearts

E. MOUSSEAUX*,{dagger},, F. BEYGUIT{dagger}, P. FORNES{ddagger}, G. CHATELLIER§, A. HAGÈGE||, M. DESNOS||, D. LECOMTE{ddagger} and J.C. GAUX*,{dagger}

*Cardiovascular Radiology Department, Broussais Hospital Paris, France
{dagger}INSERM—U256 – Instrumentation and Cardiovascular Dynamics, Broussais Hospital Paris, France
{ddagger}Institute of Forensic Medecine Paris, France
§Biostatistics and Medical Informatics Department, Broussais Hospital Paris, France
||Cardiology Department, Boucicaut Hospital Paris, France

Received 4 October 1993; revised 14 February 1994; .

Correspondence: Dr Elie Mousseaux, Radiologie Cardiovasculaire, Hopital Broussais. 96 rue Didot, 75014 Paris, France

Abstract

This study firstly determined the accuracy of left ventricular mass (LVM) determination by electron beam CT in normal and distorted human cadaver hearts, and secondly the in vivo reproducibility of these measurements, in normal subjects and patients with various cardiac diseases, over a wide range of LVM(104–631 g). In cadaver hearts, there was a close correlation between electron beam CT and autopsy LVM values: r=0.97, SEE=16 g. Intra-observer variability: results of LVM measurements obtained in cadaver hearts by observer 1 and in in vivo studies by observer 2 were y=1.001 x –1.34, r=0.99, SEE=6g and y=0.99 x +3.78, r=0.99, SEE=19 g, respectively. Inter-observer variability: results in cadaver and in vivo studies were y=1.05 x –5.94, r=0.98, SEE=14 g and y=1.13 x –23, r=0.99, SEE=28 g, respectively. Thus, these results over a wide LVM range provide extensive validation of electron beam CT measurements in hearts with marked left ventricular distortion. This method should play a valuable role, within the scope of clinical research, in assessing left ventricular remodelling in various conditions in which echocardiographic data are inaccurate.

Key Words: Electron beam CT • left ventricular mass • hypertrophic cardiomyopathy • dilated cardiomyopathy • myocardial hypertrophy


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