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European Heart Journal 1994 15(8):1028-1036;
Copyright © 1994 by the European Society of Cardiology.
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© 1994 The European Society of Cardiology

Coronary risk factors and a 20-year incidence of coronary heart disease and mortality in a Mediterranean industrial population

The Manresa study, Spain

L. TOMÁS-ABADAL*,, C. VARAS-LORENZO*, E. BERNADES-BERNAT{dagger} and I. BALAGUER-VINTRÓ*

*Department of Cardiology, Hospital de Sant Pau Barcelona, Spain
{dagger}Occupational Health Center, Pirelli Factory S.A. Manresa, Barcelona, Spain

Received 5 November 1993; revised 13 March 1994; .

Correspondence Dr L Tomás-Abadal, Departamento de Cardiologia, Hospital de Sant Pau, C/San Antonio Ma Claret 167, Barcelona 08025, Spain

Abstract

The association between coronary risk factors measured at entry and 20-year coronary heart disease (CHD) incidence and mortality was studied in an industrial cohort of 1059 men aged 30 to 59 years and free of CHD in 1968, in Spain. Myocardial infarction and fatal CHD cases were diagnosed according to recognized criteria. Mean serum cholesterol was 223.3 mg. dl–1 and 67% of men were current smokers. Rates of CHD incidence, CHD mortality and all-causes mortality, per 105 persons-year of observation, were 476, 194 and 617, respectively. Age, serum cholesterol, plasma glucose, cigarettes smoked and systolic blood pressure (SBP) contributed to the risk of CHD incidence. The first four variables predicted CHD death risk. All-causes death risk was positively associated with age, plasma glucose and SBP tevels. Results are consistent with prior reported low CHD mortality and morbidity rates in the Mediterranean area, and confirm the importance of coronary risk factors in this low-risk population.

Key Words: Blood pressure • plasma glucose • prospective study • serum cholesterol • smoking • risk of coronary heart disease


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