Copyright © 1994 by the European Society of Cardiology.
© 1994 The European Society of Cardiology
Na,K-pump concentration in hypertrophied human hearts
*Department of Cardiology, University of Oslo, Ullevål Hospital Norway
Institute for Experimental Medical Research, University of Oslo, Ullevål Hospital Norway
Department of Pathology, University of Oslo, Ullevål Hospital Norway
Received 14 July 1993; revised 23 March 1994; .
Correspondence. Øyvind Ellingesen, MD, PhD, Institute for Experimental Medical Research, Ullevål Hospital, N-0407 Oslo, Norway.
Abstract
Several studies have associated myocardial dysfunction with reduced myocardial Na, K-pump concentration, but whether impaired Na, K-pump capacity is a pathogenetic factor or an epiphenomenon related to accompanying cardiac hypertrophy is not established. We measured Na, K-pump concentrations in 10 hypertrophied and 11 normal weighted hearts obtained at autopsy using [3H]ouabain as ligand. Specific [3H] ouabain binding site concentration (OBC) in the left ventricle (L V) averaged 449 ± 40 (pmol. g –1 wet weight; mean ± SEM) in hypertrophied and 598 ± 36 in normal weighted ventricles (P=0.02). A trend towards lower LV OBC ( –19% P=0.25) was found in hypertrophied hearts from patients with congestive heart failure as compared with non-failing hypertrophied hearts. In multivariate analysis with 18 variables including age and heart failure, only LV weight correlated independently with LV OBC (r= –0.61; P=0.003). When OBC was related to either dry weight or to protein content, a 25–35% reduction was consistently found in hypertrophied LV, whereas RV OBC was similar in both groups. In conclusion, myocardial Na, K-pump concentration and thus the capacity to maintain homeostasis is reduced in LV, but not in RV, of hypertrophied hearts. Whether the moderately reduced myocardial Na, K-pump concentration is a pathogenetic factor in LV dysfunction remains to be determined.
Key Words: Myocardium • hypertrophy • congestive heart failure • sodium/potassium pump • cardiac glycosides
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