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European Heart Journal 1994 15(Supplement C):74-77; doi:10.1093/eurheartj/15.suppl_C.74
Copyright © 1994 by the European Society of Cardiology.
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© 1994 The European Society of Cardiology

The Clinical Significance of Insulin Resistance in the Treatment of Hypertension

M. Berger and P. T. Sawicki

Department of Metabolic Diseases and Nutrition, Heinrich-Heine-University Düsseldorf Düsseldorf, Germany

Correspondence: Prof. Dr Michael Berger, MNR-Klinki, Universität Düsseldorf, Moorenstraβe 5, D-40225 Düsseldorf, Germany

A strong association between arterial hypertension and Type 2 diabetes mellitus has been known for more than 70 years. However, there are many unanswered questions with regard to the hypothesis of a causal relationship between insulin resistance/hyperinsulinaemia and arterial hypertension. At present, there is no hard evidence for a close (causal) linkage between insulin resistance (or hyperinculinaemia) and arterial hypertension. Currently available antihypertensive drugs in prudent and effective dosages do not result in a deterioration of insulin sensitivity, or in the development of insulin resistance, or an increased incidence of Type 2 diabetes mellitus.

Key Words: Hypertension • insulin resistance • hyperinsulinaemia • metabolic syndrome


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