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European Heart Journal 1994 15(Supplement D):104-107; doi:10.1093/eurheartj/15.suppl_D.104
Copyright © 1994 by the European Society of Cardiology.
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© 1994 The European Society of Cardiology

Cloning, Expression and Regulation of Angiotensin II Receptors

T. Inagami, N. Iwai, K. Sasaki, Y. Yamano, S. Bardhan, S. Chaki, D. F. Guo, H. Furuta, K. Ohyama, Y. Kambayashi, K. Takahashi and T. Ichiki

Department of Biochemistry, Vanderbilt University School of Medicine Nashville, TN, U.S.A.

Correspondence: Tadashi Inagami, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville TN 37232-4146, U.S.A.

Angiotensin II isoform 1 (AT1) receptor cDNAs were cloned by expression cloning from bovine adrenal and rat vascular smooth muscles. Human AT1 receptor was also cloned. Seven transmembrane structures emerged. A single type of receptor seems to interact with more than one type of G-protein. AT1 consists of subtypes AT1A and AT1B, and the regulation of the receptors occurs at many stages. The isoform AT2 was also expression cloned from rat pheochromocytoma cells. Although its ligand binding is not affected by GTP analogs, it is a seven transmembrane domain receptor. It mediates the inhibition of phosphotyrosine phosphatase by angiotensin II and AT2 specific CGP42112A; the inhibition was abolished by pertussis toxin Thus, AT2 belongs to a new class of angiotensin receptors with unique signalling and regulatory mechanisms.

Key Words: Ang II receptors • subtypes • cDNA • cloning • regulation


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