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European Heart Journal 1994 15(Supplement D):123-128; doi:10.1093/eurheartj/15.suppl_D.123
Copyright © 1994 by the European Society of Cardiology.
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© 1994 The European Society of Cardiology

Dose-Response Relationships of ACE Inhibitors and Angiotensin II Blockers

H. R. Brunner, J. Nussbergr and B. Waeber

Hypertension Division, University Hospital Lausanne, Switzerland

Correspondence: Hans R. Brunner, MD, Hypertension Division, CHUV, 1011 Lausanne, Switzerland

It is difficult to establish dose-response relationships for ACE inhibitors in patients with hyperternion or congestive heart failure. This has led to the widely held opinion that the effects of ACE inhibitors are hardly dose dependent. The purpose of this short discussion is to demonstrate that this class of compounds, as well as the more recent angiotemin II receptor antagonists, exhibit some very clear dose-response relationships when these are evaluated in normal volunteers based on the mechanisms for which they were designed. Characterization of these dose-response curves is important in order to use these drugs at their optimol dose and to obtain the maximal therapeutic benefit.

Key Words: Angiotensin I • angiotensin II • pressure response to angiotensin • plasma drug levels


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