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European Heart Journal 1994 15(Supplement D):24-29; doi:10.1093/eurheartj/15.suppl_D.24
Copyright © 1994 by the European Society of Cardiology.
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© 1994 The European Society of Cardiology

Angiotensin I Converting Enzyme Gene: Regulation, Polymorphism and Implications in Cardiovascular Diseases

F. Soubrier, S. Nadaud and T. A. Williams

INSERM U36, Paris, France

Correspondence: F. Soubrier, INSERM 36, Collège de France, 3, rue d'Ulm, 75005 Paris, France

Angiotensin I converting enzyme (ACE), also called dipeptidyl-carboxypeptidase I (DCP I), is a zinc metallopeptidase widely distributed on the surface of endothelial and epithelial cells. Its role in the vasoactive peptide, the metabolism of the two active peptides, angiotensin and bradykinin, and the beneficial effects of its inhibition in cardiovascular diseases, have raised considerable interest in this enzyme. The potential implications of ACE gene polymorphism, which affects the expression of the gene in cardiovascular diseases, has been widely investigated. This review summarizes the results of these studies.

Key Words: Insertion/deletion polymorphism • major gene • myocardial infarction • left ventricular hypertrophy


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