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European Heart Journal 1994 15(Supplement D):58-62; doi:10.1093/eurheartj/15.suppl_D.58
Copyright © 1994 by the European Society of Cardiology.
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© 1994 The European Society of Cardiology

Phenotypic determinants of heart rate variability in cardiac hypertrophy and failure

F. Carré*, P. Maison-Blanche{dagger}, P. Mansier, B. Chevalier, N. Charlotte, T. Dakhli, P. Coumel{dagger} and B. Swynghedauw

* U 127-INSERM-Hopital Lariboisiére, Paris, Department of Physiology, University of Rennes Paris, France
{dagger} U 127-INSERM-Hopital Lariboisiére, Centre de Rythmologie, Hopital Lariboisiére Paris, France

Correspondence: B. Swynphedauw, U 127-IVSFRM. Hopital Lariboisiére 41Bd de la Chapelle, 75010. Paris, France

Reduced heart rate variability (HRV) has a strong predictive value in terms of sudden death, as compared to other prognostic criteria, but it has never been previously studied in experimental models of cardiac hypertrophy and failure. However, it has been quantified in rats using Holler monitoring and the peak and trough method of analysis. In normal rats, as in humans, short and long oscillations, sensitive, respectively, to atropine and propranolol were detected. Both correlate with heart rate. Cardiothyrotoxicosis was characterized by tachycardia and, independently, by a pronounced alteration in long oscillations. HRV was normal in compensatory cardiac hypertrophy due to aortic stenosis, but in this model the normal correlation existing between HRV and heart rate had disappeared. It is suggested that the main determinants of the above modifications of HRV are the changes in the new myocardial phenotype observed in terms of β-adrenoceptor and muscarinic densities.

Key Words: Rat • heart rate variability • myocardial phenotype • autonomous system • adrenergic receptors • muscarinic receptors • cardiac hypertrophy • Fourier transformation • peak and trough • chaotic behaviour


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