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European Heart Journal 1994 15(Supplement D):88-91; doi:10.1093/eurheartj/15.suppl_D.88
Copyright © 1994 by the European Society of Cardiology.
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© 1994 The European Society of Cardiology

Functional Significance of Angiotensin Receptors in Human Myocardium

Significant Differences Between Atrial and Ventricular Myocardium

C. Holubarsch, S. Schmidt-Schweda, A. Knorr, J. Duis, B. Pieske, T. Ruf, R. Fasol*, A. Hasenfuss and H. Just

Department of Cardiology and Angiology, Internal Medicine Freiburg, Germany
* Department of Cardiovascular Surgery, University of Freiburg Freiburg, Germany

Correspondence: Prof. Dr Ch. Holubarsch, University of Freiburg, Dept. of Cardiology and Angiology, Internal Medicine, Hugstetter Straβe 55, 79106 Freiburg, Germany

We studied the effects of angiotensin (Ang) I and II in a variety of isolated human cardiac tissues contracting under physiological conditions (37°C, 60 beats.min–1). Ang I and II consistently increased the peak developed force of human atrial muscles by 30–40%, an effect that was completely blocked by 10–1 m saralasine, but not by the combination of prazosin and propranolol. However, neither Ang I or II had significant inotropic effects in right and left ventricular human preparations. We were also able to demonstrate that the positive inotropic effect of Ang II in human right atrial tissue is mediated by the AT1 receptor subtype but not the AT2 receptor subtype.

Key Words: Angiotensin • myocardium • inotropism • angiotensin converting enzyme • angiotensin receptor subtypes


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