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European Heart Journal 1994 15(Supplement D):98-103; doi:10.1093/eurheartj/15.suppl_D.98
Copyright © 1994 by the European Society of Cardiology.
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© 1994 The European Society of Cardiology

Angiotensin II Receptor Subtypes and Cardiac Function

M. De Gasparo*,, H. Rogg*, M. Brink{dagger}, L. Wang{ddagger}, S. Whitebread*, G. Bullock{ddagger} and P. Erne§

* Cardiovascular Research Department, Pharmaceuticals Division, CIBA-GEIGY Limited Basel
{dagger} Morphology Group, Pharmaceuticals Division, Ciba-Geigy Ltd Basel
{ddagger} Department of Research, University Hospital Basel
§ Division of Cardiology, Kantonsspital Lucerne, Switzerland

Correspondence. M. de Gasparo, Cardiovascular Research Department, Pharmaceuticals Division. K 125-1015, Ciba-Gcigy Ltd, 4002 Basel, Switzerland

All the components of the renin-angiotensin system have been identified in the heart including the angiotensin II receptor subtypes AT1 and AT2

In the normal human heart, there is a decreasing receptor density from the right atrium to the left ventricle. In right atrial membranes prepared from pathological hearts, the percentage of AT1 receptor decreases with the severity of cardiac dysfunction whereas that of AT2 receptor increases. Treatment of hypertrophic rats with AT1 receptor antagonists inhibits cardiac hypertrophy and reverses the increase receptor density, indicating involvement of this Ang II receptor subtype. The role of the AT2 receptor is still largely unknown but it may be involved in cell growth and proliferation. The cloning of both AT1 and AT2 receptors as well as the availability of potent and selective antagonists will help us to understand better the functional role of Angiotensin II in cardiovascular disorders.

Key Words: AT1 • receptor subtype • AT2 receptor subtype • human heart • heart failure


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