Skip Navigation

European Heart Journal 1995 16(2):232-242;
Copyright © 1995 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by PALATINI, P.
Right arrow Articles by PESSINA, A. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by PALATINI, P.
Right arrow Articles by PESSINA, A. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1995 The European Society of Cardiology

Above-normal left ventricular systolic performance during exercise in young subjects with mild hypertension

P. PALATINI, S. BONGIOVÌ, L. MARIO, C. SCHIRALDI*, L. MOS and A. C. PESSINA

Clinica Medical, University of Padova Italy
*Fisiopatologia respiratoria, University of Padova Italy

Received 8 March 1994; revised 20 July 1994; accepted 1 August 1994.

Correspondence: Prof. Paolo Palatini, Clinica Medica I — Università di Padova. via Giustiniani, 2, 35126 Padova, Italy.

Abstract

Debate continues on whether left ventricular (LV) systolic function during exercise is abnormal in young subjects with mild hypertension and on whether the abnormal blood pressure (BP) trend observed in hypertensives during prolonged exercise is due to impaired LV function.

LV function was measured by means of M-mode echocardiography during prolonged exercise in 13 physically trained, young, mild hypertensives and 12 age-matched, trained normotensives with similar working capacity.

Systolic BPIend-systolic volume (SBPIESV) and end-systolic stress/ESV at rest were greater in the hypertensives (P<0.0001 and P–0.034), while LV filling was impaired (P–0.05). BP clianges during the first 20 min of exercise were similar in the two groups, but thereafter the between-group BP difference tended to decline progressively. LV diastolic dimension was similar at rest. During exercise it slightly increased in the normotensives and slightly decreased in the hypertensives (P–0.032). Exercise ejection fraction (P–0.018), SBPIESV (P<0.0001) and stress/ESV (P–0.027) were greater in the hypertensives throughout the test. SBPIESV normalized for LV wall thickness (P<0.0001) and the changes in SBPIESV from rest to exercise were also greater in the hypertensives (P–0.002). Stroke volume increased to a lower extent in the hypertensives, but the between-group difference was not statistically significant. The increase in SBPIESV from rest to exercise was related to the concentric remodelling of the ventricle in the hypertensives (P<0.0001) and the subjects grouped together (P<0.0001), but not in the normotensives.

In conclusion, increased LV systolic performance is present early in hypertension not only at rest but also during vigorous exercise. It is partly due to concentric remodelling of the left ventricle and partly to enhanced inotropic state.

Key Words: LV systolic performance • LV contractility • echocardiography • hypertension • diastolic function • exercise


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.