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European Heart Journal 1995 16(9):1215-1222;
Copyright © 1995 by the European Society of Cardiology.
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© 1995 The European Society of Cardiology

Monitoring of mixed venous oxygen saturation and pressure from biosensors in the right ventricle A 24 hour study in patients with heart failure

Å OHLSSON, R. BECK, T. BENNETT, R. NORDLANDER, J. RYDÉN, H. ÅSTRÖM and L. RYDÉN

Departments of Cardiology and Thoracic Physiology, Karolinska Hospital Stockholm, Sweden New Indications Research, Medtronic Inc Minneapolis, MN, U.S.A.

revised 10 October 1994; accepted 28 October 1994.

Correspondence: Åke Ohlsson M.D., Department of Cardology, Karolinska Hospital, Box 110 S-171 76 Stockholm, Sweden.

Abstract

Right ventricle venous oxygen saturation was studied in 10 heart failure patients over 24 h using a lead equipped with an oxygen biosensor inserted temporarily. At the same time a pressure sensor, incorporated in the same lead to measure right ventricular pulse pressure and maximum positive and negative rate of pressure development (RV dPldt), was tested to see whether it would interfere with the oxygen sensor. Data from the biosensor lead were continuously compared with mixed venous oxygen saturation obtained from a fibreoptic Swan-Ganz catheter with the tip in the pulmonary artery. For reference, blood samples were drawn at regular intervals from this catheter. A provocative protocol was used to cause haemodynamic changes.

There was good correlation between oxygen saturation in the right ventricle (biosensor-derived) and mixed venous oxygen saturation in the pulmonary artery (fibreoptic-derived) (r = 0.86) and between sensor-obtained right ventricular oxygen saturation and oxygen saturation in the blood samples from the pulmonary artery (r = 0.90). Changes in central haemodynamics were also well reflected by changes in pulse pressure and dPldt derived from the pressure sensor. As it was not possible to obtain absolute pressures no attempt was made to compare the pressure changes with conventional haemodynamics.

These 24 h haemodynamic measurements suggest that a biosensor-equipped lead placed in the right ventricle could be a valuable tool for long-term monitoring of mixed venous oxygen saturation and pressure in patients with congestive heart failure.

Key Words: Oxygen saturation • pressure • right ventricle • hadmodynamics • monitoring


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