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European Heart Journal 1995 16(Supplement A):54-59; doi:10.1093/eurheartj/16.suppl_A.54
Copyright © 1995 by the European Society of Cardiology.
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© 1995 The European Society of Cardiology

Recent Progress in the Clinical Aspects of Fibrinogen

W. Koenig

Department of Internal Medicine II (Cardiology), University of Ulm Medical Centre Ulm, Germany

Correspondenc: W. Koenig, Department of Internal Medicine II (Cardiology), University of Ulm Medical Centre, Ulm. Germany.

This article provides an overview of recently accumulated evidence on the pathogenetic role of fibrinogen in various vascular beds; and tries to elucidate determinants for patients' susceptibility so that subgroups at particular risk of severe clinical complications can be characterized more accurately. Based on the considerably elevated risk of cardiovascular complications associated with increased levels of plasma fibrinogen, the potential value of lowering fibrinogen in the primary or secondary prevention of atherosclerotic disease is now recognized as an important topic for consideration. Recent progress in this field will also be reviewed.

Key Words: Fibrinogen • ischaemic heart disease • stroke • peripheral arterial disease • haemostasis • platelet aggregation • diabetes • cytokines • fibrates • statins • antiplatelet drugs • angiotensin-converting enzyme inhibitors • thrombolytic agents • apheresis


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