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European Heart Journal 1995 16(Supplement B):126-131; doi:10.1093/eurheartj/16.suppl_B.126
Copyright © 1995 by the European Society of Cardiology.
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© 1995 The European Society of Cardiology

Antibiotic prophylaxis for infective endocarditis from an international group of experts towards a European consensus

C. Leport, D. Horstkotte, D. Burckhardt and Group of Experts of the International Society for Chemotheraphy

Claude Bernard Hospital, Paris 7 University Paris, France
Heinrich Heine University Dusseldorf, Germany
University Hospital Basel, Switzerland

Correspondence: C. Leport, Bichat-Claude Bernard Hospital, Department of Infectious Diseases, 46 rue Henri Huchard, 75877 Paris Cedex 18, France.

Antibiotic prophylaxis for infective endocarditis is recommended for cardiac patients at risk who undergo an at-risk procedure. Efforts should focus on patients with the highest risk, i.e. those with a prosthetic valve undergoing a dental procedure. Amoxicillin is the main recommendation in patients who are not allergic to penicillin. In patients allergic to penicillin clindamycin orally or vancomycin intravenously are proposed. Aminoglycosides are added for gastrointestinal or urological procedures.

Key Words: Prophylaxis • antibiotics • infective endocarditis • cardiac risk • procedures at risk

*The Group of Experts was organised by C.Carbon, Paris, France and E.Rubinstein, Tel-Aviv, Israel and comprised Al Halees, Riyadh, Saudi Arabia, W. G. Daniel, Hanover, Germany, D. Durack, Durban, U.S.A., P. Francioli, Lausanne, Switzerland, E. Gutschik, Copenhagen, Denmark, K. Ngu Blakett, Yaounde, Cameroun, N. A. Simmons, London, U.K., D. Stamboulian, Buenous Aires, J.T.M. Van der Meer, Amsterdam, The Netherlands, W. Wilson, Rochester, U.S.A.


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