Skip Navigation

European Heart Journal 1995 16(Supplement C):20-23; doi:10.1093/eurheartj/16.suppl_C.20
Copyright © 1995 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Charlemagne, D.
Right arrow Articles by Swynghedauw, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Charlemagne, D.
Right arrow Articles by Swynghedauw, B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1995 The European Society of Cardiology

Myocardial phenotypic changes in Na+, K+ATPase in left ventricular hypertrophy: pharmacological consequences

D. Charlemagne and B. Swynghedauw

U127-INSERM, Hopital Lariboisieère Paris, France

Correspondence: B. Swynghedauw, U127-INSERM, Hopital Lariboisieère, 41 Bd de la Chapelle, 75010, Paris France

Cardiac adaptation to permanent overload induces several phenotypic changes which finally result in a system which works more economically, together with a slower Vmax. The molecular target of digitalis is the NA+, K+ ATPase, which is a polymorphic molecule. We have recently demonstrated that during cardiac hypertrophy this target is modified and that a shift occurs in the {alpha}1 subunit, from the normally present {alpha}2 isosubunit to {alpha}3, which is a fetal isoform with a lower affinity for sodium and a higher affinity for ouabain. Such a shift explains why, in rat cardiac hypertrophy ouabain is less toxic than normal and is released from its target more slowly. It may also explain at least in part the discrepancies observed in clinical trials on the efficacy of digitalis

Key Words: Na+ pump • cardiac hypertrophy • glycoside therapy • digitalis


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Am Coll CardiolHome page
A. Frustaci, N. Magnavita, C. Chimenti, M. Caldarulo, E. Sabbioni, R. Pietra, C. Cellini, G. F. Possati, and A. Maseri
Marked elevation of myocardial trace elements in idiopathic dilated cardiomyopathy compared with secondary cardiac dysfunction
J. Am. Coll. Cardiol., May 1, 1999; 33(6): 1578 - 1583.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.