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European Heart Journal 1995 16(Supplement C):66-68; doi:10.1093/eurheartj/16.suppl_C.66
Copyright © 1995 by the European Society of Cardiology.
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© 1995 The European Society of Cardiology

Control of coronary angiogenesis

W. Schaper

Max-Planck-Institute, Department of Experimental Cardiology, Bad Nauheim Germany

Correspondence: Prof. Dr. Wolfgang Schaper, Max-Planck-Institute, Department f Experimental Cardiology, Benekestrasse 2, D-61231 Bad Nauheim. Germany.

We investigated the development of coronary collaterals in canine and porcine models using either progressive experimental coronary occlusion or microembolism of small vessels. Muscular arteries developed on the epicardial surface of canine - but not of porcine hearts, where large, thin-walled intra-myocardial capillaries developed irrespective of the type of vascular occlusion. The common motif for both types of vascular adaptation is the part played by inflammation, i.e. the involvement of monocytes/macrophages that are probably the producers of growth factors. Emphasis is placed on the importance of remodelling by controlled proteolysis to create the space for the new vascular cells

Key Words: growth factors • arterial remodeling • collateral circulation


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