Skip Navigation

European Heart Journal 1995 16(Supplement K):31-36; doi:10.1093/eurheartj/16.suppl_K.31
Copyright © 1995 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Vaughan, D. E.
Right arrow Articles by Pfeffer, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vaughan, D. E.
Right arrow Articles by Pfeffer, M. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1995 The European Society of Cardiology

Role of the fibrinolytic system in preventing myocardial infarction

D. E. Vaughan*,, J.-L. Rouleau{dagger} and M. A. Pfeffer{ddagger}

* Cardiology Division, Vanderbilt University Medical Center and Veterans Affairs Medical Center Nashville, TN
{dagger} Montreal Heart Institute Montreal, Canada
{ddagger} Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School Boston, MA

Correspondence: Douglas E. Vaughan, MD, Vanderbilt University School of Medicine, Division of Cardiology, Rm 315 MRB II, 2220 Pierce Avenue, Nashville, TN 37232-6300, U.S.A.

Activation of the renin-angiotensin system (RAS) has been implicated in the pathogenesis of acute myocardial infarction (AMI). Similarly, red ucedfibrinolytic activity has been associated with an increased risk of AMI. Evidence is now accumulating that the RAS plays an important role in the regulation offibrinolysis and that pharmacological interruption of the RAS exerts a positive effect on endogenousfibrinolytic balance. This relationship appears to provide a partial explanation for the newly recognized effect of angiotensin converting enzyme inhibitors in preventing AMI.

Key Words: Fibrinolysis • renin-angiotensin system • plasminogen activator inhibitor-1 • tissue-type plasminogen activator • angiotensin converting enzyme


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.