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European Heart Journal 1995 16(Supplement O):18-19; doi:10.1093/eurheartj/16.suppl_O.18
Copyright © 1995 by the European Society of Cardiology.
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© 1995 The European Society of Cardiology

A non-cardiovirulent strain of coxsackievirus B3 causes myocarditis in mice with severe combined immunodeficiency syndrome

G. Hufnagel, N. Chapman* and S. Tracy*

Philipps University of Marburg, Department of Cardiology Baldingerstraβe, D-35033 Marburg, Germany
* Department of Pathology and Microbiology, University of Nebraska Medical Center 600 South 42nd Street, Omaha, NE 68198, U.S.A.

Dr Günter Hufnagel. ZIM. Abteilung Kardiologie. Baldingerstraβe, D-35033 Marburg. Germany.

The most extensively studied animal model of coxsackievirus B3 (CVB3) -induced inflammatory heart muscle disease is the murine model. In the acute and chronic phase of the disease, it has been suggested that autoimmune mechanisms play a major role in the pathogenesis of the disease. In this study, C3H mice without functional T- and B-lymphocytes (C3H SCID) were inoculated either with a cardiovindent (CVB3/20) or a non-cardiovirulent (CVB3/0) strain of coxsackievirus B3. Both viruses caused myocarditis in SCID mice. Furthermore, it could be demonstrated, that CVB3/0 had mutated to a cardio-virulent phenotype, able to cause myocarditis in immunocompetent mice.

Key Words: Coxsackievirus B3 • enterovirus • inflammatory heart disease • myocarditis • SCID • mice


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