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European Heart Journal 1995 16(Supplement O):20-24; doi:10.1093/eurheartj/16.suppl_O.20
Copyright © 1995 by the European Society of Cardiology.
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© 1995 The European Society of Cardiology

New aspects of murine coxsackie B3 myocarditis—focus on heavy metals

N. G. Ilbäck*,{dagger},, U. Lindh{dagger}{dagger},¶, J. Fohlman{dagger} and G. Friman{dagger}

* Toxicology and Safety Assessment Pharmacia AB, Helsingborg
{dagger} Department of Infectious Diseases, University Hospital, Uppsala University Uppsala
{dagger}{dagger} Division of Biomedical Radiation Science, Uppsala University Uppsala
Centre for Metal Biology in Uppsala Uppsala, Sweden

Nils-Gunnar IIback. PhD. Toxicology and Safety Assessment. Kabi Pharmacia AB. PO Box 941. S-251 09 Helsingborg, Sweden.

The magnitude of inflammatory lesions in the hearts of coxsackie B3 (CB3)-virus infected mice can be affected by the potentially toxic heavy metals cadmium (Cd), nickel (Ni) and methyl mercury (MeHg). The infection is associated with a changed distribution, such as Cd accumulation in the spleen and kidneys. New target organs for Ni during the infection were the heart, pancreas and lungs in which inflammatory lesions were present. This increased uptake was correlated with the disturbed function of immune cells and an increased inflammatory reaction. Ni and MeHg appeared to have a direct effect on immune cells that resulted in changed natural killer cell activity and decreased mobilization of macrophages, CD4+ and CD8+ cells into the inflammatory lesions. Although MeHg increased spleen T cell activity and {gamma} interferon (IFN-{gamma}) levels, the inflammatory lesions in the heart increased. Another detrimental effect of MeHg treatment was evident by an increased calcium and decreased zinc content in the inflamed heart, which may partly explain the more severe inflammatory lesion. The host's response, CB3 infection, changed the distribution of each metal in a specific way, a fact which may subsequently result in altered target organ toxicity and resistance to the infection.

Key Words: Coxsackei B3 • myocarditis • heavy metal


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