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European Heart Journal 1995 16(Supplement O):64-67; doi:10.1093/eurheartj/16.suppl_O.64
Copyright © 1995 by the European Society of Cardiology.
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© 1995 The European Society of Cardiology

The role of the ADP/ATP carrier in the pathogenesis of viral heart disease

K. Schulze and H. P. Schultheiss*

Medizinische Klinik B, Heinrich-Heine Universit&t Düsseldorf
* KHnik fur Kardiologie, Universitdtsklinikum Benjamin-Franklin Berlin-Steglitz, Germany

Karsten Schulze, MD, Medizinische Klinik B. Heinrich-Heine Universitat. Moorenstr. 5.40225 Dusseldorf. Germany.

The ADP/ATP carrier is an autoantigen in myocarditis and dilated cardiomyopathy, both of which are diseases related to virus infections. Sera of these patients bear carrier-specific autoantibodies inhibiting transmembrane nucleotide transport on isolated mitochondria. To further assess the role of the A DP/A TP carrier in viral heart disease, guinea pigs were immunized with the isolated ADP/ATP carrier protein and A-strain mice were infected with coxsackie B3 virus.Both species generated specific and carrier-inactivating antibodies after immunization/infection. The transport activity of the ADP/ATP carrier—estimated from the cytosolic-mitochondrial difference of the phosphorylation potential of ATP (AGfcyt-mitJ)—markedly declined in guinea pig and mice hearts. A close relationship was observed between the magnitude of reduction of AG(cyt-mit) and the decrease of cardiac function. Therefore, it seems plausible that carrier dysfunction induced by viral infection creates an imbalance in myocardial energy metabolism, and is responsible for the impairment of cardiac function. The underlying mechanism might be an autoimmune reaction triggered via molecular mimicry or a modulation of the expression of ADP/ATP carrier isoforms changing the overall transport capacity of the cardiac ADP/ATP carrier.

Key Words: ADP/ATP carrier • phosphorylation potential • myocarditis • cardiomyopathy • viral heart disease


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