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European Heart Journal 1995 16(Supplement O):71-74; doi:10.1093/eurheartj/16.suppl_O.71
Copyright © 1995 by the European Society of Cardiology.
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© 1995 The European Society of Cardiology

Cellular immune mechanisms in myosin-induced myocarditis

C. Pummerer, G. Grässl and N. Neu

Department of Pediatrics, Medical School, University of Innsbruck Austria

Correspondence: Dr Nikolaus Neu, Department of Pediatrics, Medical School, University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria

Cardiac myosin-induced myocarditis proved to be a valuable virus-free murine model with which to investigate auto-immunological mechanisms in inflammatory heart disease. The disease was shown to be T cell-mediated. In this contribution the functional role ofCD4 and CD8 molecules and the conditions that are required to make the cardiac tissue susceptible to an autoimmune attack are discussed

Key Words: Autoimmune myocarditis • myosin, cellular immunity • adoptive transfer • lipopolysaccharides


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