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European Heart Journal 1995 16(Supplement O):75-77; doi:10.1093/eurheartj/16.suppl_O.75
Copyright © 1995 by the European Society of Cardiology.
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© 1995 The European Society of Cardiology

An ultrastructural study on experimental autoimmune myocarditis with special reference to effector cells

T. Izumi, K. Suzuki, M. Saeki, Y. Ookura, S. Hirono, T. Inomata, H. Hanawa and M. Kodama

First Department of Internal Medicine, Niigata University School of Medicine Nügata, Japan

Correspondence: Tohru Izumi MD, First Department of Internal Medicine, Niigata University School of Medicine, Asahimachi 1-754, Niigata 951, Japan

The previously described animal model of autoimmune myocarditis induced by immunization of Lewis rats with cardiac myosin was investigated pathologically, ultrastructurally and immunohistologically. Cardiac dendritic cells and infiltrating macrophages were dominantly encamped at the front of the myocarditis. The macrophages accompanied by neutrophils infested cardiocytes, forming rosette figures as a sign of active cardiocytolysis. The dendritic cells reached into intact muscle at a short distance from the inflammation. T cells, the most important candidate for effector cells in this animal model, were generally found at a distance from active muscle necrosis.

Key Words: Autoimmune myocarditis • effector cells


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