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European Heart Journal 1995 16(Supplement O):78-80; doi:10.1093/eurheartj/16.suppl_O.78
Copyright © 1995 by the European Society of Cardiology.
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© 1995 The European Society of Cardiology

Molecular biological and quantitative abnormalities of ADP/ATP carrier protein in cardiomyopathic hamsters

M. Kato, S. Yamashina*, N. Takeda, S. Mochizuki, T. Morishita* and M. Nagano{dagger}

Department of Internal Medicine, Aoto Hospital, Jikei University School of Medicine Tokyo, Japan
* Jikei University Tokyo
{dagger} First Department of Internal Medicine, Toho University Tokyo, Japan
University School of Medicine Tokyo, Japan

M. Kato. Department of Internal Medicine, Aoto Hospital. Jikei University. 6-41-2 Aoto. Katsushika, Tokyo 125. Japan.

The adenine nucleotide translocator or ADP/ATP carrier protein (AAC) is an integral protein present in the inner mito-chondrial membrane, which performs the exchange of cytoplasmic and intramitochondrial ADP and ATP. The myocardial AAC content was studied in J-2-N cardiomyopathic hamsters. The AAC content was found to be significantly decreased in J-2-N hamsters. For molecular biological analysis, hamster AAC (TI isoenzyme) cDNA was cloned by the plaque hybridization method. This AAC cDNA hybridized specifically with AAC mRNA, so RNA dot-blot hybridization was performed. The highest AAC mRNA level was observed in control hamsters followed by J-2-N hamsters with mild myocardial damage, J-2-N hamsters with severe myocardial damage and Bio 14-6 cardiomyopathic hamsters. These results suggest that a decreased AAC content may contribute to the pathogenesis of cardiomyopathy and that a decrease of AAC mRNA levels may explain the abnormalities of AAC in J-2-N cardiomyopathic hamsters.

Key Words: ADP/ATP carrier protein • adenine nucleotide translocator • cardiomyopathic hamster


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