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European Heart Journal 1995 16(Supplement O):85-88; doi:10.1093/eurheartj/16.suppl_O.85
Copyright © 1995 by the European Society of Cardiology.
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© 1995 The European Society of Cardiology

The β1-adrenoceptor as antigen: functional aspects

G. Wallukat, A. Kayser and A. Wollenberger

Max-Delbruck-Centrum fur Molekulare Medizin Berlin, Germany

Dr G. Wallukat, Max-Delbriick-Centrum fur Molekulare Medizin, 13125 Berlin, Germany.

The sera of patients with myocarditis and idiopathic dilated cardiomyopathy contain agonistic autoantibodies that bind to the β1-adrenoceptor. These antibodies recognize epitopes on either the first or second extracellular loop of this receptor and exert in cultured neonatal rat heart myocytes a positive chronotropic effect. This effect is eliminated by β1-adrenoceptor blockade as well as by peptides corresponding to the first or second extracellular loop of the human β1adrenoceptor. The antibodies realize their effects mainly via the β -adrenoceptor-adenylate cyclase-protein kinase A cascade.

Key Words: Autoimmunity • antiβ1-adrenoceptor antibodies • epitope analysis • myocarditis • dilated cardiomyopathy • cyclic AMP


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