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European Heart Journal 1996 17(10):1503-1505;
Copyright © 1996 by the European Society of Cardiology.
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© 1996 The European Society of Cardiology

Increased levels of plasma thrombomodulin are associated with vascular and all-cause mortality in patients on long-term anticoagulant treatment

J.-H. Jansson*, K. Boman*, M. Brännström* and T. K. Nilsson{dagger}

*Departrnent of Medicine, Skellefteå Hospital Umeå, Sweden
{dagger}Department of Clinical Chemistry, Umeå University Hospital Umeå, Sweden

revised 6 February 1996; accepted 12 February 1996.

Dr J.-H. Jansson. Department of Medicine, Skellefteå Hospital, S-93186 Skellefteå Sweden

Abstract

BACKGROUND: The aim of the study was to test if plasma levels of thrombomodulin could predict mortality in 209 patients on long-term anticoagulant treatment followed up for 38 years.

METHODS AND RESULTS: The thrombomodulin level was 60·9 ± 29·8 µg. 1–1 for all 45 patients who died and 60·5 ± 30·5 .µg. 1–1 for the 38 vascular deaths, compared to 52·3 ± 20·7 µg. 1–1 for the 164 survivors. We found that, in Cox regression analyses, all-cause (P=0·025) and vascular mortality (P=0·042) was significantly and independently associated with increased levels of thrombomodulin.

CONCLUSIONS: The level of plasma thrombomodulin can predict all-cause and vascular mortality in patients on long-term anticoagulant treatment.

(Eur Heart J 1996; 17: 1503–1505)

Key Words: Anticoagulants • vascular mortality • risk factors • thrombomodulin


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