Copyright © 1996 by the European Society of Cardiology.
© 1996 The European Society of Cardiology
Determinants of lipoprotein(a) levels in a middle-aged working population
*Department of Public Health, University Gent De Pintelaan 185, B-9000 Gent, Belgium
Department of Biochemistry, University Gent Hospitaalstraat 13, B-9000 Gent, Belgium
Received 28 February 1996; accepted 12 March 1996.
Correspondence: Lutgart Braeckman, Department of Public Health, University Hospital, De Pintelaan 1985. B-9000 Gent. Belgium
Abstract
BACKGROUND: The association between blood lipids, apolipoproteins, fibrinogen, life-style-related factors and lipoprotein(a) was assessed in a cohort of middle-aged men.
METHODS: Male employees, working in local industry, were invited to participate in a health survey at their worksite. After exclusion of nine persons with prevalent diabetes and 14 subjects with a history of myocardial infarction or angina, data were available on 720 healthy Caucasian men.
RESULTS: Lipoprotein(a) concentration was measured using an enzyme-linked immunosorbent assay (ELISA), and distribution was found to be highly skewed with a median level of 9mg. dl–1 (mean level 23.1 mg . dl–1). The percentage of subjects with lipoprotein(a) levels higher than 30 mg. dl–1 was 23.6%. Univariate analysis showed a significant association between lipoprotein(a) and age, total cholesterol, apolipoprotein B and fibrinogen. However, no relationship was found with body mass index, waist to hip ratio, smoking, blood pressure, alcohol consumption, diet, HDL cholesterol, apolipoprotein Al and apolipoprotein E concentration or apolipoprotein E polymorphism. In multivariate analysis, In-transformed lipoprotein(a) correlated positively with apolipoprotein B (P<0.0001) and fibrinogen (P=0.004). Proportional changes in lipoprotein(a) concentration were predicted in relation to specified changes in biochemical and lifestyle variables. A 20 mg. d–1 increase in apolipoprotein B and a 75 mg. dl–1increase in fibrinogen levels were estimated to increase lipoprotein(a) concentration by 29.4% and 2l.5% respectively.
CONCLUSIONS: Our data confirm the existence of an independent association between lipoprotein(a) and fibrinogen and give evidence for correlation with apolipoprotein B.
Key Words: Lipids • apolipoproteins • cardiovascular disease • fibrinogen • risk factors
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