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European Heart Journal 1996 17(Supplement B):17-20; doi:10.1093/eurheartj/17.suppl_B.17
Copyright © 1996 by the European Society of Cardiology.
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© 1996 1996 The European Society of Cardiology

Beta-blockers in heart failure—the evidence from clinical trials

J. R. Hampton

Queen's Medical Centre University Hospital, Nottingham, UK

Correspondence: J. R. Hampton DM MA DPhil FRCP FFPM, Professor of Cardiology, Cardiovascular Medicine, Queen's Medical Centre, University Hospital, Nottingham NG7 2UH, U.K.

There are good theoretical reasons for supposing that long-term treatment with a beta-blocker would improve symptoms and survival in patients with heart failure. A series of small studies have shown that beta-blockers improve haemodynamic parameters, but it is well known that these correlate poorly with symptoms. There is some evidence that exercise tolerance is also improved. Although there is so far no convincing evidence that beta-blockers prolong survival in patients with heart failure the development of a new generation of these drugs with additional vasodilating properties makes further large studies essential.

Key Words: Heart failure • clinical trials • beta-blockers


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