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European Heart Journal 1996 17(Supplement D):15-19; doi:10.1093/eurheartj/17.suppl_D.15
Copyright © 1996 by the European Society of Cardiology.
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© 1996 1996 The European Society of Cardiology

Cardioprotective effects of ovarian hormones

G. M. C. Rosano, S. L. Chierchia, F. Leonardo, C. M. Beale* and P. Collins*

Department of Cardiology, Istituto H. San Raffaele Milano-Roma, Italy
* Division of Cardiac Medicine, National Heart & Lung Institute and Royal Brompton Hospital London, UK

Correspondence: Dr G. M. C. Rosano, Department of Cardiology, Istituto H. San Raffaele, Via Elio Chianesi 33, 00144 Roma, Italy

This paper reviews the evidence regarding the cardioprotective effects of oestrogen replacement therapy in postmenopausal women. Oestrogens have been shown to improve serum lipid profiles, carbohydrate metabolism, and insulin sensitivity; prevent the formation and development of atherosclerotic plaque; reduce blood pressure and plasma fibrinogen levels; and favourably affect overall cardiac function. Thus, oestrogen replacement therapy may prevent or inhibit the progression of existing coronary disease, and may also have a protective effect against acute cardiovascular and cerebrovascular ischaemic events.

Key Words: Atherosclerosis • coronary artery disease • ischaemia • oestrogen replacement therapy • postmenopausal women


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