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European Heart Journal 1996 17(Supplement D):20-26; doi:10.1093/eurheartj/17.suppl_D.20
Copyright © 1996 by the European Society of Cardiology.
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© 1996 1996 The European Society of Cardiology

Physiological effects of ovarian hormones

Clinical aspects and compliance

B. Ottesen and A. T. Pedersen

Department of Obstetrics and Gynaecology, Hvidovre Hospital, University of Copenhagen Hvidovre, Denmark

Correspondence: Bent Ottesen MD, DSc, Department of Obstetrics and Gynecology, Hvidovre Hospital, University of Copenhagen, DK-2650 Hvidovre, Denmark

Menopause is marked by the permanent cessation of menstrual bleeding. Deprivation of ovarian hormones due to decreasing ovarian activity causes widespread physiological effects. Disturbances in menstrual pattern and hot flashes are major reasons for hormone replacement therapy (HRT), but prevention of osteoporosis and cardiovascular disease are other considerations. Despite the large number of different hormone treatment regimens available, such problems as continued bleeding and concern about side effects engenders low compliance. To enhance compliance, it is important to ensure that post-menopausal women and their physicians are aware of the probable risks and benefits of hormone therapy before deciding whether or not to use preventive HRT.

Key Words: Menopause • hormone replacement therapy • cardiovascular disease


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