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European Heart Journal 1996 17(Supplement D):27-31; doi:10.1093/eurheartj/17.suppl_D.27
Copyright © 1996 by the European Society of Cardiology.
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© 1996 1996 The European Society of Cardiology

Oestrogen as a calcium channel blocker

P. Collins, C. M. Beale and G. M. C. Rosano*

Department of Cardiac Medicine, National Heart and Lung Institute and Royal Brompton Hospital London, UK
* Department of Cardiology, Istituto H. San Raffaele Roma, Italy

Correspondence: Dr P. Collins, Department of Cardiac Medicine, National Heart and Lung Institute and Royal Brompton Hospital, Dovehouse Street, London SW3 6LY, U.K.

This paper reviews the evidence for calcium-antagonist properties of oestrogen which may offer long-term protective effects on the cardiovascular system in postmenopausal women. Oestrogen has already been shown to have a beneficial effect on cholesterol metabolism and deposition, thereby inhibiting the formation of atherosclerotic plaque and coronary atheroma. Calcium antagonism, resulting in both acute and chronic modulation of coronary and peripheral vasomotion, is another mechanism by which oestrogens may provide cardiovascular benefits to women, including those with existing cardiovascular disease.

Key Words: Atherosclerosis • calcium antagonism • cardiovascular disease • myocardial ischaemia • oestrogen replacement therapy • post-menopausal women


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