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European Heart Journal 1996 17(Supplement E):35-41; doi:10.1093/eurheartj/17.suppl_E.35
Copyright © 1996 by the European Society of Cardiology.
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© 1996 1996 The European Society of Cardiology

Clinical markers of thrombolytic success

V. Pasceri, F. Andreotti and A. Maseri

Institute of Cardiology, Catholic University Rome, Italy

Correspondence: Dr V. Pasceri, Institute of Cardiology, Catholic University, Largo A. Gemelli 8, 00168 Roma, Italy

Although a number of markers of successful coronary thrombolysis have been proposed, only a few of these have the two necessary features of a clinically useful marker: (1) widespread early availability and (2) good predictive value. The reduction in ST-segment elevation on the standard 12 lead electrocardiogram 1–4 h after initiation of thrombo lysis may be the simplest and most useful clinical ‘tool’ to gauge the effectiveness of thrombolytic therapy. The predictive value of this single marker might be further improved by combining it with assessment of the rate of increase of serum myoglobin and of troponin T, provided these determinations were rapidly available.

Key Words: Acute myocardial infarction • thrombolysis • coronary recanalization • markers of reperfusion • ECG monitoring • serum myoglobin • troponin T


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