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European Heart Journal 1996 17(Supplement G):48-52; doi:10.1093/eurheartj/17.suppl_G.48
Copyright © 1996 by the European Society of Cardiology.
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© 1996 1996 The European Society of Cardiology

The pathophysiology of myocardial ischaemia

J-M. R. Detry

Division of Cardiology, Saint-Luc University Hospital, University of Louvain Brussels, Belgium

Correspondence: Professor J-M. R. Detry, Service de Cardiologie, Cliniques Universitaries St. Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium.

In this review paper on the pathophysiology of myocardial ischaemia, the recent concepts of the ischaemic cascade, as well as the concepts of stunning and hibernating myocardium, are discussed. It is clear that painful ischaemia is the final phenomenon in the ischaemic cascade and that it is preceded by biochemical disturbances, diastolic and systolic dysfunction and electrocardiographic abnormalities. Silent ischaemia remains a difficult research field. (Eur Heart J 1996; 17 (Suppl G): 48–52)

Key Words: Ischaemic heart disease • pathophysiology • diagnosis


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