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European Heart Journal 1996 17(Supplement G):59-63; doi:10.1093/eurheartj/17.suppl_G.59
Copyright © 1996 by the European Society of Cardiology.
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© 1996 1996 The European Society of Cardiology

Circadian variations in total ischaemic burden and ischaemic threshold

D. Tzivoni

Department of Cardiology, Jesselson Heart Center, Shaare Zedek Medical Center Jerusalem, Israel

Correspondence: Professor Dan Tzivoni, Director, Department of Cardiology, Shaare Zedek Medical Center, PO Box 3235, 91030 Jerusalem, Israel.

Myocardial ischaemia in daily life varies according to a circadian rhythm and is induced by many factors, including both increased myocardial oxygen demand and changes in coronary tone. In most patients, ischaemia is induced by a combination of different contributing factors, although the relative contribution of each mechanism varies from patient to patient. Moreover, in the same individual, various episodes may be due to different mechanisms. The relative contributions of increased myocardial oxygen demand and decreased ischaemic threshold to the development of ischaemia in daily life can be assessed by continuous ambulatory ECG monitoring which may help to optimize medical anti-ischaemic therapy. (Eur Heart J 1996; 17 (Suppl G): 59–63)

Key Words: Ischaemic heart disease • circadian rhythms • continuous ambulatory ECG Monitoring


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