Skip Navigation

European Heart Journal 1997 18(1):52-59;
Copyright © 1997 by the European Society of Cardiology.
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Behar, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Behar, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1997 The European Society of Cardiology

Low total cholesterol is associated with high total mortality in patients with coronary heart disease

S. Behar, E. Graff*, H. Reicher-Reiss, V. Boyko, M. Benderly, A. Shotan, D. Brunner and for the Bezafibrate Infarction Prevention (BIP) Study Group*

Neufeld Cardiac Research Institute, Sheba Medical Center Tel Hashomer, Israel
*Institute of Physiological Hygiene, Edith Wolfson Medical Center Holon, Israel

Received 28 February 1996; accepted 3 April 1996.

Correspondence: S. Behar, BIP Coordinating Centre, Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Hashomer 52621, Israel

Abstract

The present non-intervention screening study was undertaken to explore the relationships between pre-existing low total cholesterol and all-cause mortality. Eleven thousand, five hundred and sixty-three patients with coronary heart disease who attended a screening visit but were not included in the Bezafibrate Infarction Prevention study were followed-up for a mean of 3·3 years after determination of baseline total cholesterol. Five hundred and ninety-five (5%) of this largely unselected population who had total cholesterol levels ≤ 160 mg. dl–1 formed the study population. The remaining 10 968 patients acted as controls. The relative risk of all-cause mortality among patients with low cholesterol compared to others was 1·49 (95% CI: 1·16–1·91). The relative risk of non-cardiac death was 2·27 times higher in the low cholesterol group than in the controls (95· CI: 1·49–3·45), whereas the risk of cardiac death was the same in both groups (relative risk 1·09; 95% CI: 0·76–1·56). The most frequent cause of non-cardiac death associated with low total cholesterol was cancer. These results in patients with coronary heart disease add weight to previous studies associating low total cholesterol with an increased risk of non-cardiac death. However, a longer follow-up of this cohort of patients is necessary in order to clarify this association.

Key Words: Total cholesterol • coronary heart disease • cardiac mortality • non-cardiac mortality


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 JAMAHome page
Y. Liu, J. Coresh, J. A. Eustace, J. C. Longenecker, B. Jaar, N. E. Fink, R. P. Tracy, N. R. Powe, and M. J. Klag
Association Between Cholesterol Level and Mortality in Dialysis Patients: Role of Inflammation and Malnutrition
JAMA, January 28, 2004; 291(4): 451 - 459.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
Y. Cui, R. S. Blumenthal, J. A. Flaws, M. K. Whiteman, P. Langenberg, P. S. Bachorik, and T. L. Bush
Non-High-Density Lipoprotein Cholesterol Level as a Predictor of Cardiovascular Disease Mortality
Arch Intern Med, June 11, 2001; 161(11): 1413 - 1419.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.