Skip Navigation

European Heart Journal 1997 18(12):1890-1896;
Copyright © 1997 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Norrsell, H.
Right arrow Articles by Friberg, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Norrsell, H.
Right arrow Articles by Friberg, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1997 The European Society of Cardiology

Effects of pacing-induced myocardial stress and spinal cord stimulation on whole body and cardiac norepinephrine spillover

H. Norrsell*,, T. Eliasson*, C. Mannheimer*, L.-E. Augustinsson{dagger}, C.-H. Bergh{ddagger}, B. Andersson{ddagger}, F. Waagstein{ddagger} and P. Friberg§

*Multidisciplinary Pain Centre, Department of Medicine, Östra Hospital Göteborg, Sweden
{dagger}Departments of Neurosurgery, Sahlgren's University Hospital Göteborg, Sweden
{ddagger}Departments of Cardiology, Sahlgren's University Hospital Göteborg, Sweden
§Departments of Clinical Physiology, Sahlgren's University Hospital Göteborg, Sweden

Received 13 June 1997; accepted 20 June 1997.

Correspondence: Henrik Norrsell, MD, Multidisciplinary Pain Centre, Department of Medicine, Östra Hospital S-416 85 Gothenburg, Sweden

Abstract

AIMS: Spinal cord stimulation has been used in the treatment of intractable angina pectoris since the beginning of the 1980s. This study was designed to investigate whether the documented anti-ischaemic effects of spinal cord stimulation are mediated through a decrease in sympathetic activity.

METHODS AND RESULTS: Ten patients with a spinal cord stimulator implanted as anti-anginal treatment were included in the study. Atrial pacing until the patient experienced moderate angina was performed and after 50 min rest the procedure was repeated during spinal cord stimulation. Total body and cardiac norepinephrine spillover was calculated and the former was found to have increased during pacing (47%, P=0·02). When spinal cord stimulation was applied, total body norepinephrine spillover decreased at a comparable pacing rate (18%, P=0·02). Cardiac norepinephrine spillover was not affected during the procedure.

CONCLUSION: The results of this study indicate that the anti-ischaemic effect of spinal cord stimulation is not due to reduced cardiac sympathetic activity. However, spinal cord stimulation decreases overall sympathetic activity which may benefit the heart, possibly by reducing oxygen demand.

Key Words: Spinal cord stimulation • sympathetic activity • angina pectoris • atrial pacing


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 CirculationHome page
Z. F. Issa, X. Zhou, M. R. Ujhelyi, J. Rosenberger, D. Bhakta, W. J. Groh, J. M. Miller, and D. P. Zipes
Thoracic Spinal Cord Stimulation Reduces the Risk of Ischemic Ventricular Arrhythmias in a Postinfarction Heart Failure Canine Model
Circulation, June 21, 2005; 111(24): 3217 - 3220.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
C. Mannheimer, P. Camici, M.R. Chester, A. Collins, M. DeJongste, T. Eliasson, F. Follath, I. Hellemans, J. Herlitz, T. Luscher, et al.
The problem of chronic refractory angina. Report from the ESC Joint Study Group on the Treatment of Refractory Angina
Eur. Heart J., March 1, 2002; 23(5): 355 - 370.
[Full Text] [PDF]

Home page
 HeartHome page
S Murray, P D Collins, and M A James
Neurostimulation treatment for angina pectoris
Heart, February 1, 2000; 83(2): 217 - 220.
[Full Text]

Home page
 HeartHome page
S Murray, K G S Carson, P D Ewings, P D Collins, and M A James
Spinal cord stimulation significantly decreases the need for acute hospital admission for chest pain in patients with refractory angina pectoris
Heart, July 1, 1999; 82(1): 89 - 92.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.