Copyright © 1997 by the European Society of Cardiology.
© 1997 The European Society of Cardiology
C-reactive protein as a marker for acute coronary syndromes
,
Cardiology Center, Department of Medicine, University Hospital Geneva, Switzerland
Clinic of Medicine, Department of Medicine, University Hospital Geneva, Switzerland
Emergency Center, Department of Medicine, University Hospital Geneva, Switzerland
||Central Clinical Chemistry Laboratory, Department of Medicine, University Hospital Geneva, Switzerland
Received 26 June 1997; accepted 10 July 1997.
Correspondence: François Mach, Vascular Medicine and Atherosclerosis Unit, Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, LMRC 309, Boston, MA 02115, U.S.A.
Abstract
BACKGROUND: For several years, acute coronary syndromes have been perceived as causing the most hospital admissions, and even hospital mortality. The syndrome of unstable angina frequently progresses to acute myocardial infarction but its pathogenesis is poorly understood, and prognosis determination is still problematic. We tested the hypothesis that measurement of the C-reactive protein in patients admitted for chest pain could be a marker for acute coronary syndromes.
METHODS AND RESULTS: We studied 110 patients admitted with suspected ischaemic heart disease, but without elevated serum creatine-kinase levels at the time of hospital admission. Patients were subsequently divided into two groups based on their final diagnosis: group 1 comprised patients with unstable angina; group 2 patients with acute myocardial infarction. We measured the C-reactive protein at the time of hospital admission. The concentration of C-reactive protein was elevated in 59% of the patients with a final diagnosis of acute myocardial infarction, and in 5% of the patients with a final diagnosis of unstable angina, (P<0·001).
CONCLUSION: This study indicates that C-reactive protein levels measured at the time of admission in patients with suspected ischaemic heart disease could be a marker for acute coronary syndromes, and helpful in identifying patients at high risk for acute myocardial infarction. Measurement of C-reactive protein may have practical clinical significance in the management of patients hospitalized for suspected acute coronary syndromes.
Key Words: Acute coronary syndromes • C-reactive protein
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