Copyright © 1997 by the European Society of Cardiology.
© 1997 The European Society of Cardiology
Clinical epidemiology of venous thromboembolic disease
Results of a French Multicentre Registry
revised 1 October 1996; accepted 2 October 1996.
Correspondence: Emile Ferrari, MD, Department of Cardiology, 30 Avenue de la Voie Romaine, 06002 Nice, France
Abstract
OBJECTIVE: Between July 1992 and December 1994, 16 French hospital centres, mainly cardiological, participated in a non-controlled observational study on venous thromboembolic disease. The objective of this survey was to collect data concerning the current status of pulmonary embolism and deep venous thrombosis.
PATIENTS: During this period, 547 patients were included: 446 with deep venous thrombosis and 387 with pulmonary embolisms.
RESULTS: Mean age of patients was 63±21 years. There were no significant differences between the sexes. Pulmonary embolism and deep venous thrombosis tended to occur more frequently during the autumn and winter. In 30% of cases, prior deep venous thrombosis or pulmonary embolism was noted. No cause was found for the condition in 47% of cases. Ultrasound (echocardiography and/or venous ultrasound) was the most frequently requested investigation. Intravenous heparin remains the most widely used treatment (76%). Oral anticoagulation was begun before day 3 in less than 31% of cases. Thrombolytic treatment was used in 20% of pulmonary embolism cases, but was rarely prescribed for deep venous thrombosis (2·2%). The hospital recurrence rate (12/547 cases) was fairly low. The search for occult malignancy, performed in 48% of cases, seems to remain one of the major concerns of physicians. The combined pulmonary embolism and deep venous thrombosis mortality rate was 4·4%, while the death rate for pulmonary embolism alone was 6·2%.
Key Words: Pulmonary embolism • deep venous thrombosis • epidemiology • thromboembolism • clinical diagnosis • cost effectiveness
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